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Pharmacology: Pharmacokinetics: Ascorbic acid is readily absorbed from the gastrointestinal tract and is widely distributed in the body tissues. Plasma concentration of ascorbic acid rise as the dose ingested is increased until a plateau is reached with doses of about 90 to 150 mg daily. Body stores of ascorbic acid in healthy individuals are about 1.5 g although more may be stored at intakes above 200 mg daily.
Ascorbic acid is reversibly oxidized to dehydroascorbic acid (which is less likely to happen when chelated with calcium or zinc as in this formula); some is metabolized to ascorbate-2-sulfate, which is inactive, and oxalic acid which are excreted in the urine.
Ascorbic acid in excess of the body's need is also rapidly eliminated unchanged in the urine; this generally occurs with intakes exceeding 100 mg daily.
